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Ali Arbab

Professor

Ali Arbab

Professor

Academic Appointment(s)

Medical College of Georgia
Department of Biochemistry and Molecular Biology

Medical College of Georgia
Department of Georgia Cancer Center

Administration
Department of The »Æ¹Ï¶ÌÊÓƵ School

Bio

I have 35 years of experience in imaging science, involving MRI, SPECT, CT, ultrasound, and optical imaging modalities. My laboratory is working on targeting the tumor micro-environment of glioblastoma and breast cancers using different engineered exosomes and drug-loaded nano-capsules. We are also working with stroke models to improve recovery using engineered exosomes.

Education

  • Ph.D., Medical Scientist. Yamanashi Medical University, 1998

  • MD, Medicine University of Dhaka, 1988

Awards & Honors

  • Grant Reviewer The National Institutes of Health, 2020

  • Grant reviewer California Institute of Regenerative Medicine, 2017

  • Travel Award Radiological Society of North America (RSNA), 2008

  • Fellows Award for Research Excellence (FARE) The National Institutes of Health, 2003

  • Asia-Oceania Young Investigator’s Award Japanese Society of Nuclear Medicine, 1999

Courses Taught Most Recent Academic Year

  • BIOM 8230

    Biology of Proteins in Disease

  • BCMB 8201

    Cur Topics & Tech in MB

  • BCMB 9010

    Seminar in BMB

  • CURS 2990

    Undergrad Research I

Teaching Interests

Tumor neovascularization, Biomedical Imaging,Tumor micro-environment and possible effect after chemotherapy, engineered exosomes in pathophysiology

Scholarship

Selected Recent Publications

  • Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia, 2024
    Journal Article, Academic Journal
  • Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke, 2024
    Journal Article, Academic Journal
  • Isolation and immunosuppressive functions of myeloid-derived suppressor cell-derived exosomes, 2024
    Journal Article, Academic Journal
  • Experimental study of processing of PCL (polycaprolactone)-peptides nanoparticles and its biodistribution analysis for drug delivery system, 2024
    Journal Article, Academic Journal
  • Altering biomolecular condensates as a potential mechanism that mediates cannabidiol effect on glioblastoma, 2024
    Journal Article, Academic Journal

Research Interests

> Generation of engineered exosomes to initiate ADCC of targeted cells by NK cells.
> Generation of engineered exosomes to target dying neurons in stroke
> Ultrasound-mediated delivery of exosomes to the stroke area to enhance the better outcome
> Understanding the mechanisms of resistance to antiangiogenic treatment in solid tumors.
> Targeting arachidonic acid metabolites for the treatment of solid tumors.
>Tumor cell-secreted exosomes in modulating tumor micro-environment and niche for distal metastasis.
> Generation of tissue-specific MRI and SPECT contrast agents and drug delivery systems (nano-particles).
> Understand the mechanisms of GVHD to delay it by targeting myeloid cells.

Department Service

  • Small animal core advisory committee 2020 - 2025

    Role: Committee Member

  • Director 3T human MRI core 2023 - 2025

    Role: Other

  • GCC proteomics core 2021 - 2023

    Role: Committee Member

University Service

  • PT committee of DCG 2023 - Present

    Role: Committee Member

  • ARAC 2021 - Present

    Role: Committee Member

  • Mock Study Section 2019 - 2020

    Role: Administrative Assignment, Other

  • Steering Committee 2019 - 2020

    Role: Committee Member

Professional Service

  • NIH study panel 2016 - Present

    Role: Reviewer, Grant Proposal

  • CIRM 2004 - Present

    Role: Member

  • Scientific Journals - 2020

    Role: Reviewer

  • Various scientific journals - 2020

    Role: Editorial Review Board Member