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- Effects of Remote Ischemic Conditioning on Cerebral Regional Oxygen Saturation in Adults After Ischemic Stroke
Clinical Trial
Effects of Remote Ischemic Conditioning on Cerebral Regional Oxygen Saturation in Adults After Ischemic Stroke
Most people who have a stroke caused by a blood clot (called an acute ischemic stroke) aren?t able to receive current treatments, which means many face serious long-term problems or even death. That?s why researchers are working to find better prevention and treatment options. One promising approach is called remote ischemic conditioning (RIC). It?s a simple and safe technique where a blood pressure cuff is gently inflated and deflated on both arms for short periods. This process may help improve recovery after a stroke. Previous studies show RIC can increase blood flow to the brain, but we don?t yet know how the brain uses that extra blood and oxygen. This study will explore that by using a safe, painless method called near-infrared spectroscopy (NIRS), which uses light sensors on the forehead to measure oxygen levels in the brain in real time. What the Study Involves: The study lasts approximately 3 weeks. All participants in the study will receive the same treatment. There will be 3 clinic visits: Visit 1 (Start): Participants will get their first RIC treatment at the clinic while we measure their brain oxygen levels. At Home (Day 2-13): Participants will perform RIC treatments at home daily for 13 days. Visit 2 (Day 14
- Circulatory System
- Nervous System
- Cerebral Regional Oxygen Saturation
- Ischemic Stroke
- Near Infrared Spectroscopy
- Neuroprotection
- Remote Ischemic Conditioning
Eligibility Criteria
- Inclusion Criteria Adults 18 years of age or older. Able to walk & be independent in basic activities of daily living. Able to understand study procedures and agree with a valid consent. History of ischemic stroke diagnosis Ability to receive RIC treatment to bilateral upper extremities. Ability to understand and read English. Exclusion Criteria Unable to use the RIC device for any reason. A confounding illness that might interfere with the interpretation of results (such as active malignancy or multiple sclerosis) Contraindication to arm ischemia (such as severe peripheral artery disease) Dementia BMI > 40 Pregnant