The Surendra Rajpurohit Lab
Surendra Rajpurohit, PhD, FAHA
Research Scientist
Department of Biochemistry & Molecular Biology
Medical College of Georgia
Department of Biological Sciences
College of Science and Mathematics
Georgia Cancer Center
Jump to: Research SummaryImpact on Georgia patientsResearch Focus Research Interests Publications
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The Rajpurohit Lab
Health Sciences Campus
1410 Laney Walker Blvd, CN 3117
(706) 721-0277
Research Summary
Dr. Rajpurohit’s lab is working on Experimental Therapeutics in Glioblastoma Tumor Microenvironment, and Cardio-oncology using an in-multi modeling system, which includes: In-silico modeling system, in-vitro modeling system, in-vivo transparent transgenic zebrafish and mouse models, and high throughput (HT) drug discovery, repurposing of FDA-approved drugs, identification of novel hit and lead drugs, and drug validation and drug toxicity in glioblastoma and cardio-oncology therapeutics.
The laboratory studies the cancer drug induced cardio toxicity, Identification of the novel drug candidate to mimic cancer drug induced cardio vascular complications, mitochondria function, cell death process (role of annexin 5 and inflammatory activity of NF-kB) in the microglia-resident macrophages of the brain (normal and in glioblastomas) and cardiac myocytes (normal and inflamed) in transgenic zebrafish and mouse models.
Impact on Patients in Georgia
Georgia’s state public health system and workforce is fundamental to the health and well-being of Georgians. Improving the health of all Georgians means placing an intentional focus on public health and prevention.
Cardiovascular disease is currently the leading cause of morbidity and mortality in the United States. Unfortunately, a side effect of some cancer therapies is the development of cardiovascular disease. Cardio-oncology is a specialized field focused on preventing, monitoring, and treating cardiovascular disease caused by cancer therapies. It bridges cardiology and oncology to optimize patient health, allowing for effective cancer treatment with minimal, manageable heart damage. This is one area of our research. Precision cardio oncology medicine represents a transformative approach to healthcare, focusing on tailoring medical treatments and interventions to the unique characteristics of each patient, thus affecting the health of all Georgians.
In addition, Dr. Rajpurohit actively trains and mentors »Æ¹Ï¶ÌÊÓƵ undergraduates through the Center for Undergraduate Research & Scholarship (CURS), HONORS Thesis program, External Research Volunteers training Program, and other related mentoring programs. Training the biomedical workforce of the future is of utmost importance to the patients, citizens, and economy of the state of Georgia.
Research Focus
Dr. Rajpurohit ’s research is focused on:
- Working on the Experimental Therapeutic in Glioblastoma and Cardio-oncology by using in-vivo transparent transgenic zebrafish and mouse models.
- Developing and establishing in-vivo transparent transgenic cellular phenotype model of zebrafish to study the cell death process.
- Repurposing of FDA-approved drugs.
- Identification of novel hit and lead drugs.
- Drug validation and drug toxicity in glioblastoma and cardio oncology therapeutics.
Research Interests
Validation & Toxicology Study of K21 Drug in Zebrafish Model
This project aims to evaluate the safety, developmental effects, and overall efficacy of a proposed drug using a zebrafish model. The study will follow a phased experimental design to assess impacts on developmental dynamics, growth, behavior, teratogenicity, and toxicity. Key goals include quantifying the drug’s effects across these parameters and determining its overall influence on zebrafish health. The findings are intended to establish measurable benchmarks for safety, biological impact, and support further development.
Experimental Therapeutics
The goal of this project is to design and implement experiments that involve the development and assessment of experimental therapeutics, using various animal model systems.
View Pure Research Profile
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, Manhiani, D. A. S., , Rajpurohit, P., Hotwani, S., Nasanally, S., Sreekumar, A., Bhat, K., Derhei, A. V., Pasi, R., Mishra, A., Kimmerling, K. & Carey, C. M., Jun 2025, In: Biomedicines. 13, 6, 1267. Research output: Contribution to journal › Article › peer-review |
, Ouellette, L., Sura, S., Appiah, C., O’Keefe, A., McCarthy, K., Kandepu, U., Ye Mon, M., Kimmerling, K., & , Jul 2023, In: Biomedicines. 11, 7, 1985. Research output: Contribution to journal › Article › peer-review |
Doughty, D., , Trang, A., Alptekin, A., Korkaya, A. K., Achyut, B. R., & , Aug 2022, In: Experimental Biology and Medicine. 247, 16, p. 1433-1446 14 p. Research output: Contribution to journal › Article › peer-review |
, Gopal, A., Ye Mon, M., & , Aug 2021, In: Cells. 10, 8, 1963. Research output: Contribution to journal › Article › peer-review |
Ullah, A., Doroodchi, A., Zarate, L. V., Mattox, S. N., Sliker, T., Willhite, D. K., Khan, J., Owen, H. C., , & , Apr 2 2021, In: International journal of environmental research and public health. 18, 8, 4157. Research output: Contribution to journal › Article › peer-review |
, Dec 1 2016, In: Nature Protocols. 11, 12, p. 2432-2453 22 p. Research output: Contribution to journal › Article › peer-review |
Wang, G., , Delaspre, F., Walker, S. L., White, D. T., Ceasrine, A., Kuruvilla, R., Li, R.-J., Shim, J. S., Liu, J. O., Parsons, M. J. & Mumm, J. S., 2015, In: eLife. 4 Research output: Contribution to journal › Article › peer-review |
Urban, B. E., Neogi, P., Senthilkumar, K., , Jagadeeshwaran, P., Kim, S., Fujita, Y. & Neogi, A., 2012, In: Selected Topics in Quantum Electronics, IEEE Journal of. 18, 4, p. 1451-1456 6 p. Research output: Contribution to journal › Article › peer-review |
Jagadeeswaran, P., Carrillo, M., Radhakrishnan, U. P., & Kim, S., 2011, In: Methods in Cell Biology. 101, p. 197-203 7 p. Research output: Contribution to journal › Article › peer-review |
Jagadeeswaran, P., Radhakrishnan, U. P., Kim, S., , Xie, D. & Hsieh, J.-T., 2011, In: Cancer Research. 71, 8 Supplement, p. 4377-4377 1 p. Research output: Contribution to journal › Article › peer-review |
Carrillo, M., Kim, S., , Kulkarni, V. & Jagadeeswaran, P., Dec 15 2010, In: Blood Cells, Molecules, and Diseases. 45, 4, p. 326-33 8 p. Research output: Contribution to journal › Article › peer-review |
Kim, S., Radhakrishnan, U. P., , Kulkarni, V. & Jagadeeswaran, P., Mar 15 2010, In: Blood Cells, Molecules, and Diseases. 44, 3, p. 169-74 6 p. Research output: Contribution to journal › Article › peer-review |
Kim, S., Carlson, R., Zafreen, L., & Jagadeeswaran, P., Sep 2009, In: Zebrafish. 6, 3, p. 269-74 6 p. Research output: Contribution to journal › Article › peer-review |
, Pendse, A., Barjatiya, M. & Singh, P., 1996, In: Urolithiasis. p. 450 Research output: Contribution to journal › Article › peer-review |
Singh, P. P., Pendse, A. K., Ahmed, A., Ramavataram, D. V. & , 1995, In: Urological Research. 23, 3, p. 201-3 3 p. Research output: Contribution to journal › Article › peer-review |
, Pendse, A., Ahmed, A. & Singh, P., 1992, In: Indian Journal of Clinical Biochemistry. 7, 2, p. 205-206 2 p. Research output: Contribution to journal › Article › peer-review |
Ahmed, A., Pendse, A., & Singh, P., 1992, In: Indian Journal of Clinical Biochemistry. 7, 2, p. 171-178 8 p. Research output: Contribution to journal › Article › peer-review |
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Research Team
Antara Chaudhary
- Medical Scholar
- (2025-2029)
Sreeja Sappati
- Medical Scholar
- (2026-2030)
Timothy Pham
- Medical Scholar
- (2026-2030)
Shristhi Desai
- Undergraduate Honors Program Research
- (2025-2028)
Keyana Williams
- Undergraduate Honors Program Research
- (2024-2027)
Sai Nasavally
- Undergraduate Honors Program Research
- (2023-2026)
Sreeja Sappati
- CURS Students
- (2024-2026)
Timothy Pham
- CURS Students
- (2024-2026)
Shrusthi Desai
- CURS Students
- (2025-2029)
Hemala Kupusmay
- CURS Students
- (2024-2028)
Research Team Alumni
Survarsha Sura
- (2019-2021)
Anabelle O’keefe
- (2019-2022)
Katherine McCartney
- (2019-2022)
Rohan Kapuria
- (2020-2021)
Chelsea Appiah
- (2020-2023)
Aminah Wood
- (2022-2023)
Kunal Hotwani
- (2021-2023)
Raymond Chen
- (2022-2023)
Vaani Balyan
- (2022-2024)
Keshu Bhat
- (2022-2024)
Aiden Van Derhei
- (2022-2024)
Umasai Kandepu
May Ye Mon
Karen Aikhionbare
Logan Ouellette