Singh Laboratory
Dr. Nagendra Singh
Professor, Department of Biochemistry & Molecular Biology
Dr. Singh’s laboratory studies molecular and cellular mechanisms of underlying immune responses against pathogens and cancers. We utilize a variety of immunological, epigenetic, molecular, biochemical, and cellular techniques to study the behavior of immune cells during pathological conditions.
One of the ongoing projects in the laboratory involve studying the development, survival, and function of plasma cells. Plasma cells are factory for producing antibodies molecule that neutralize the invading pathogens. Understanding of these mechanisms is critical in designing improved vaccines against pathogens.
His other research interest includes how T cells are activated and generate immune responses and help other immune cells to successfully eliminate invading pathogens and cancers. Under this project, he is studying how T cells become exhausted or toothless during chronic infection and cancers.
Previously, he discovered the mechanism underlying dietary fiber mediated induction of anti-inflammatory mechanisms in intestine such as Treg cells leading to suppression of intestinal inflammation and cancers.
His research is funded by extramural sources such as NIH/NIAID.
Jump to: Selected Publications
Pure Publications
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Bhatt, B., Kumar, K., , Ganesan, D., Anazodo, F., Rathakrishnan, A., Zhu, H., Wanna, A., Jiang, C., Jayavelu, T., , , , Sheridan, B. S., , & , Mar 1 2025, In: Journal of immunology (Baltimore, Md. : 1950). 214, 3, p. 446-459 14 p. Research output: Contribution to journal › Article › peer-review |
Zhu, H., Sharma, A. K., Aguilar, K., Boghani, F., Sarcan, S., George, M., Ramesh, J., Van Der Eerden, J., Panda, C. S., Lopez, A., , , , Klein, K., White, J., , , & , Mar 15 2024, In: iScience. 27, 3, 109191. Research output: Contribution to journal › Article › peer-review |
Tandra, V., Anderson, T., Ayala, J. D., , , & , Aug 2023, In: Cells. 12, 15, 1923. Research output: Contribution to journal › Article › peer-review |
Zhu, H., Jiang, C., Kaufman, R. J., & , 2022, Methods in Molecular Biology. Humana Press Inc., p. 221-231 11 p. (Methods in Molecular Biology; vol. 2378). Research output: Chapter in Book/Report/Conference proceeding › Chapter |
Bridges, A. E., Ramachandran, S., Tamizhmani, K., Parwal, U., Lester, A., Rajpurohit, P., Morera, D. S., Hasanali, S. L., Arjunan, P., Jedeja, R. N., , Martin, P. M., Korkaya, H., , , , , , Ganapathy, V. & , Sep 2021, In: Molecular Cancer Research. 19, 9, p. 1486-1497 12 p. Research output: Contribution to journal › Article › peer-review |
Quintero, M., Liu, S., Xia, Y., Huang, Y., Zou, Y., Li, G., Hu, L., , Blumberg, R., Cai, Y., Xu, H. & , Jan 2021, In: Cell Death and Disease. 12, 1, 131. Research output: Contribution to journal › Article › peer-review |
Yang, W., Yu, T., Huang, X., Bilotta, A. J., Xu, L., Lu, Y., Sun, J., Pan, F., Zhou, J., Zhang, W., Yao, S., Maynard, C. L., , Dann, S. M., Liu, Z. & Cong, Y., Dec 1 2020, In: Nature communications. 11, 1, 4457. Research output: Contribution to journal › Article › peer-review |
Horimatsu, T., Blomkalns, A. L., Ogbi, M., Moses, M., Kim, D., Patel, S., Gilreath, N., Reid, L., Benson, T. W., Pye, J., Ahmadieh, S., Thompson, A., Robbins, N., Mann, A., Edgell, A., Benjamin, S., , Huo, Y., & Agarwal, G. & 4 others, , Dec 1 2020, In: Cardiovascular Research. 116, 14, p. 2226-2238 13 p. Research output: Contribution to journal › Article › peer-review |
Bridges, A. E., Ramachandran, S., Pathania, R., Parwal, U., Lester, A., Rajpurohit, P., Morera, D. S., , , Korkaya, H., , , , , Ganapathy, V. & , Sep 15 2020, In: Cancer Research. 80, 18, p. 3855-3866 12 p. Research output: Contribution to journal › Article › peer-review |
Bhatt, B., Zhu, H., & , 2020, Methods in Molecular Biology. Humana Press Inc., p. 93-98 6 p. (Methods in Molecular Biology; vol. 2121). Research output: Chapter in Book/Report/Conference proceeding › Chapter |
Cai, Y., Zhu, G., Liu, S., Pan, Z., Quintero, M., Poole, C. J., Lu, C., Zhu, H., Islam, B., Van Riggelen, J., , Liu, K., Blumberg, R., & , Dec 1 2019, In: Cell Discovery. 5, 1, 7. Research output: Contribution to journal › Article › peer-review |
Zhu, H., Bhatt, B., Sivaprakasam, S., Cai, Y., Liu, S., Kodeboyina, S. K., , , , Kaufman, R. J., & , Dec 1 2019, In: Nature communications. 10, 1, 1084. Research output: Contribution to journal › Article › peer-review |
Mitchell, A., Hasanali, S. L., Morera, D. S., Baskar, R., Wang, X., Khan, R., Talukder, A., Li, C. S., Manoharan, M., Jordan, A. R., Wang, J., , , Albo, D., & , Nov 1 2019, In: Cancer Biomarkers. 26, 3, p. 291-301 11 p. Research output: Contribution to journal › Article › peer-review |
Rajendran, M., Looney, S., , Elashiry, M., Meghil, M. M., , Tawfik, O., Susin, C., Arce Munoz, R. M. & Cutler, C. W., May 1 2019, In: Journal of Immunology. 202, 9, p. 2690-2699 10 p. Research output: Contribution to journal › Article › peer-review |
Subramani, K., Chu, X., Warren, M., Lee, M., Lu, S., & Raju, R. P., Mar 1 2019, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 3, p. 688-695 8 p. Research output: Contribution to journal › Article › peer-review |
Jadeja, R. N., Jones, M. A., Fromal, O., , Khurana, S., & Martin, P. M., Jan 1 2019, In: Aging. 11, 2, p. 386-400 15 p. Research output: Contribution to journal › Article › peer-review |
Arjunan, P., Meghil, M. M., Pi, W., Xu, J., Lang, L., El-Awady, A., Sullivan, W., Rajendran, M., Rabelo, M. S., Wang, T., Tawfik, O. K., Kunde-Ramamoorthy, G., , , Susin, C., Teng, Y., Arce Munoz, R. M. & Cutler, C. W., Dec 1 2018, In: Scientific reports. 8, 1, 16607. Research output: Contribution to journal › Article › peer-review |
Bhatt, B., Zeng, P., Zhu, H., Sivaprakasam, S., Li, S., Xiao, H., Dong, L., Shiao, S.-Y. P., , , Levy Bercowski, D., Ganapathy, V., & , Apr 15 2018, In: Journal of Immunology. 200, 8, p. 2905-2914 10 p. Research output: Contribution to journal › Article › peer-review |
Sharman, S. K., Islam, B. N., Hou, Y., , Berger, F. G., Sridhar, S., Yoo, W. & , Feb 2018, In: Cancer Prevention Research. 11, 2, p. 81-91 11 p. Research output: Contribution to journal › Article › peer-review |
Zhu, H., Lemos, H., Bhatt, B., Islam, B. N., Singh, A., Gurav, A., Huang, L., , Mellor, A., & , Sep 2017, In: PloS one. 12, 9, e0183484. Research output: Contribution to journal › Article › peer-review |
, Gurav, A., Zhu, H., Martin, P. M., Vijay-Kumar, M. & , Jul 13 2017, Dietary Fiber for the Prevention of Cardiovascular Disease: Fiber's Interaction between Gut Micoflora, Sugar Metabolism, Weight Control and Cardiovascular Health. Elsevier Inc., p. 73-90 18 p. Research output: Chapter in Book/Report/Conference proceeding › Chapter |
Sharman, S. K., Islam, B. N., Hou, Y., Usry, M., Bridges, A., , Sridhar, S., & , Apr 2017, In: PloS one. 12, 4, e0176673. Research output: Contribution to journal › Article › peer-review |
Lu, C., Talukder, A., , & Liu, K., Mar 4 2017, In: OncoImmunology. 6, 3, e1291106. Research output: Contribution to journal › Article › peer-review |
Wang, R., Islam, B. N., Bridges, A., Sharman, S. K., Hu, M., Hou, Y., Somanath, P. R., Venable, L., , Kim, S., Sridhar, S., Hofmann, F. & , Feb 1 2017, In: American Journal of Pathology. 187, 2, p. 377-389 13 p. Research output: Contribution to journal › Article › peer-review |
Kuczma, M. P., Ding, Z.-C., Li, T., Habtetsion, T., Chen, T., Hao, Z., , , Kochenderfer, J. N. & , 2017, In: Oncotarget. 8, 67, p. 111931-111942 12 p. Research output: Contribution to journal › Article › peer-review |
Islam, B. N., Sharman, S. K., Hou, Y., Bridges, A. E., , Kim, S., , Trillo-Tinoco, J., Rodriguez, P. C., Berger, F. G., Sridhar, S. & , 2017, In: Cancer Prevention Research. 10, 7, p. 377-388 12 p. Research output: Contribution to journal › Article › peer-review |
Sivaprakasam, S., & , Aug 1 2016, In: Pharmacology and Therapeutics. 164, p. 144-151 8 p. Research output: Contribution to journal › Review article › peer-review |
Cai, Y., & , Jun 1 2016, In: Experimental Hematology. 44, 6, p. 442-446 5 p. Research output: Contribution to journal › Review article › peer-review |
Sivaprakasam, S., Gurav, A., Paschall, A. V., Coe, G. L., Chaudhary, K., Cai, Y., , Martin, P., , Huang, L., Shi, H., , Vijay-Kumar, M., , , Mellor, A., McGaha, T. L., Shiao, P., Cutler, C. W. & Liu, K. & 3 others, , 2016, In: Oncogenesis. 5, 6, e238. Research output: Contribution to journal › Article › peer-review |
Zhang, M., Zhu, X., Zhang, Y., Cai, Y., Chen, J., Sivaprakasam, S., Gurav, A., Pi, W., Makala, L. H., Wu, J., Pace, B. S., Tuan Lo, D., Ganapathy, V., & , Dec 1 2015, In: Cell Death and Differentiation. 22, 12, p. 1922-1934 13 p. Research output: Contribution to journal › Article › peer-review |
Cai, Y., Pi, W., Sivaprakasam, S., Zhu, X., Zhang, M., Chen, J., Makala, L. H., Lu, C., Wu, J., Teng, Y., Pace, B. S., Tuan Lo, D., & , Nov 2015, In: PLoS Genetics. 11, 11, e1005643. Research output: Contribution to journal › Article › peer-review |
Gurav, A., Sivaprakasam, S., Bhutia, Y. D., Boettger, T., & Ganapathy, V., Jul 15 2015, In: Biochemical Journal. 469, 2, p. 267-278 12 p. Research output: Contribution to journal › Article › peer-review |
Singh, V., Chassaing, B., Zhang, L., San Yeoh, B., Xiao, X., Kumar, M., Baker, M. T., Cai, J., Walker, R., Borkowski, K., Harvatine, K. J., , Shearer, G. C., Ntambi, J. M., Joe, B., Patterson, A. D., Gewirtz, A. T. & Vijay-Kumar, M., 2015, In: Cell Metabolism. 22, 6, p. 983-996 14 p. Research output: Contribution to journal › Article › peer-review |
Promsote, W., Makala, L., Li, B., Smith, S. B., , Ganapathy, V., Pace, B. S. & Martin, P. M., Aug 2014, In: Investigative ophthalmology & visual science. 55, 8, p. 5382-5393 12 p. Research output: Contribution to journal › Article › peer-review |
Vadivel, G., , , Martin, P. M. & , Apr 1 2014, Butyrate: Food Sources, Functions and Health Benefits. Nova Science Publishers, Inc., p. 157-176 20 p. Research output: Chapter in Book/Report/Conference proceeding › Chapter |
Coothankandaswamy, V., Elangovan, S., , , & Ganapathy, V., Feb 15 2013, In: Biochemical Journal. 450, 1, p. 169-178 10 p. Research output: Contribution to journal › Article › peer-review |
Zimmerman, M. A., , Martin, P. M., , Ganapathy, V., , , Robertson, K. D., & Liu, K., Jun 15 2012, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 12, p. G1405-G1415 Research output: Contribution to journal › Article › peer-review |
Karunakaran, S., Ramachandran, S., Coothankandaswamy, V., Elangovan, S., Babu, E., Periyasamy Thandavan, S., Gurav, A., Gnana-Prakasam, J. P., , , , & Ganapathy, V., Sep 9 2011, In: Journal of Biological Chemistry. 286, 36, p. 31830-31838 9 p. Research output: Contribution to journal › Article › peer-review |
Zimmerman, M., Yang, D., Hu, X., Liu, F., , , Ganapathy, V., Chandler, P., Choubey, D., Abrams, S. I. & Liu, K., 2010, In: PloS one. 5, 11, e14076. Research output: Contribution to journal › Article › peer-review |
, , & , Jun 2009, In: Endocrine. 35, 3, p. 389-396 8 p. Research output: Contribution to journal › Article › peer-review |
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