The Goldstein Laboratory

Ali Eroglu

Evan Goldstein, PhD

Assistant Professor, Neuroscience

Research Summary

Brain damage induced by premature birth is the leading cause of neurodevelopmental disabilities. Research in my lab investigates the pathogenesis and repair of diffuse white matter injury – the most common neuropathological outcome of premature birth. Clinical studies demonstrate that environmental factors can benefit recovery from white matter injury, however specific mechanisms driving progression and recovery are not well understood. Our previous work found that recovery in an enriched environment ameliorates developmental brain injury and promotes functional recovery. The current focus in the lab is to identify how environmental stimuli direct cell and molecular changes in the brain. Using a mouse model of diffuse white matter injury or postmortem preterm infant brain samples, we are investigating the role of histone modifications in white matter injury. Our studies will inform the quest to develop improved therapeutic options for babies born preterm.

Contact Us

The Goldstein Lab

Health Sciences Campus

(706) 723-4391

egoldstein@augusta.edu

Research Interests

The Goldstein Lab is on focused on developmental brain injury, myelin, and epigenetics.

 

 

Selected Publications

  • Abbah J*, Vacher CM*, Goldstein EZ*#, Li Z, Kundu S, Talbot B, Bhattacharya S, Hashimoto-Torii K, Wang L, Banerjee P, Scafidi J, Smith NA, Chew LJ, Gallo V#. Oxidative stress-induced damage to the developing hippocampus is mediated by GSK3beta. J Neurosci. 42 (24) 4812-4827, 2022. PMID: 35589394.

*Authors contributed equally. # Co-corresponding authors.

 

  • Goldstein EZ#, Pertsovskaya V, Forbes TA, Dupree JL, Gallo V#. Prolonged Environmental Enrichment Promotes Developmental Myelination. Front Cell Dev Biol, 9:665409; 2021. PMID: 33981706

# Co-corresponding authors.

 

  • Forbes TA*, Goldstein EZ*, Dupree JL, Jablonska B, Scafidi J, Adams KL, Imamura Y, Hashimoto-Torii K, Gallo V. Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery. Nat Commun, 11(1), 964; 2020. PMID: 32075970

*Authors contributed equally

 

  • Goldstein EZ, Church JS, Pukos N, Gottipati MK, Popovich PG, McTigue DM. Intraspinal TLR4 activation promotes iron storage but does not protect neurons or oligodendrocytes from progressive iron-mediated damage. Exp Neurol, 298(Pt A): 42-56; 2017. (Selected for cover art)

 

  • Goldstein EZ, Church JS, Hesp ZC, McTigue DM. Silver lining of inflammation: The beneficial effects of inflammation on myelination. Exp Neurol, 283(B): 550-559; 2016.